Supplements for Better Brain Health and Function

brain health and function supplements

How do you attain better brain health and function? Eating a healthy diet comes to mind, as does regular exercise and challenging your brain daily by staying mentally active. But what about supplements? Are there supplements for better brain health and function?

Eating for better brain health and function

Following a nutritious diet does more than fuel your body; it stokes and energizes your brain. If you don’t properly nourish your brain with certain essential nutrients, then you risk a decline in cognitive function and an increased risk for neurodegenerative disease. Before discussing the best supplements for better brain health and function, let’s look at diet.

Read about building better brain health naturally

A diet that was specially developed to promote brain health, support brain function, and help reduce the risk of developing dementia, including Alzheimer’s disease, is called the MIND diet. It stands for Mediterranean-DASH Intervention for Neurodegenerative Delay and takes components from two highly acclaimed diets—Mediterranean and DASH—that focus on enhancing brain health.

The MIND diet was voted 4th best overall diet in 2023 by US News & World Report, while its “parents” were voted 1st and 2nd (Mediterranean and DASH, respectively) for 2023 and have consistently been in the top two for many years. Research shows that people who adopted a diet very close to the MIND diet had about a 53 percent lower risk of developing Alzheimer’s disease.

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Even if you follow the MIND diet, adding supplements may boost the benefits. Let’s explore some nutrients available in supplements that can help with better brain health and function.

Supplements for better brain health and function

What supplements might you need to help enhance or fill in the gaps in your diet to support your brain health and function? Here are eight candidates that have research to back them up.

Aged garlic extract (AGE)

Aged garlic extract is a supplement produced by aging fresh organic garlic at room temperature in an aqueous ethanol solution for up to 20 months. The result is a highly bioavailable product that has undergone some significant changes. For example, the garlic becomes odor-free and is easily digestible. It also loses its harsh organosulfur compound known as allicin, which is transformed into mild substances called S-allylmercaptocystine (found only in AGE) and S-allylcysteine.

Research has shown that AGE has neuroprotective properties that work against neuroinflammation and neurodegeneration. Two active ingredients in AGE are SAC (S-allylcysteine), which is the most abundant component, and FruArg [(N-alpha-(1-deoxy-D-fructose-1yl)-L-arginine]. All three of these substances appear to work to improve brain health. FruArg can cross the blood-brain barrier, which “further supports its potential as a therapeutic compound.”

Read about aged garlic extract: AGE for a healthier you


Carnitine is an amino acid and nutrient that is found in food and is also produced by the body from two other amino acids, lysine and methionine. Its main role in the body is to help transport fatty acids into the mitochondria in cells, where they are burned for energy.

The standard biologically active form of carnitine is L-carnitine. However, several other forms, including acetyl-L-carnitine, may be the most beneficial form for the brain. Research shows that this form of carnitine “shows promise in the treatment of aging and neurodegenerative pathologies by slowing the progression of mental deterioration.”

Folic acid

Folic acid is the supplement form of folate, the natural type of B vitamin (B9) found in food. You need folic acid to develop RNA and DNA and to form neurotransmitters in the brain. Several B vitamins, especially folic acid, are involved in brain health and memory. Research has shown that a higher intake of folate/folic acid is associated with a significantly reduced incidence of dementia.

Ginkgo biloba

Ginkgo biloba has been around for millions of years, but recently, researchers uncovered its value for brain health and function. This herb is a powerful antioxidant that can improve blood circulation in the brain and help individuals living with mild cognitive impairment. In a 2023 systemic review that included nine clinical trials involving 946 patients, they found ginkgo to be beneficial for memory, attention, executive functioning, and processing speed. Significant improvement was also seen in anxiety and depression.


Lecithin is a naturally occurring fatty acid involved in metabolic function, energy balance, and the regeneration of brain cells. More specifically, lecithin is important for the production of the neurotransmitter acetylcholine. Healthy levels of this neurotransmitter are necessary to support healthy brain function.


Phosphatidylserine is a type of fat (phospholipid) that helps protect brain cells against damage and sends signals between them, which promotes memory and cognitive function. Levels of phosphatidylserine decline as you age, which is why some people take a supplement as they age.

Siberian ginseng

Despite its name, this herb is not true ginseng. However, Siberian ginseng (Eleuthero) is an adaptogen, which means it works to help balance and manage stress in the body. Among the potential benefits of this herb is the ability to increase blood flow, including to the brain, which may improve memory, concentration, and other mental functions.

Vitamin B12

This B vitamin plays several functions in brain health. Some research has shown that people with early-stage dementia who took vitamin B12 and omega-3 fatty acids had slowed mental decline. One study noted that low levels of vitamin B12 can impact memory performance. A 2020 study in Cureus noted that “Vitamin B12 deficiency is linked to cognition, and replacement therapy may be an option to improve patient cognition outcomes.”

Bottom line

Several natural nutrients and herbs, including memory and concentration, benefit brain health and function. Kyolic Brain Focus provides ginkgo biloba for sharpness, mental acuity, and attention. Kyolic Brain Memory combines aged garlic extract, ginkgo biloba, and Siberian ginseng for better concentration, learning, and recall. Kyolic Neuro-Logic is a special formula of aged garlic extract along with carnitine, choline (from lecithin), folic acid, ginkgo biloba, phosphatidylserine, and vitamin B12 for memory, learning, and mental acuity.

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Lisa Roth Collins is a Registered Holistic Nutritionist (RHN) and is the Marketing Manager at She is passionate about health and wellness and tries her best to make healthier choices every day for herself and her family. Her journey to natural health was driven by her own struggles with digestive discomfort, depression, and anxiety. Lisa returned to school in 2014 to study nutrition at the Canadian School for Natural Nutrition. She threw herself into her studies so she could learn as much as she could to help herself feel better and thrive. Upon completing the program and being certified as an RHN, Lisa began her work at Naturally Savvy where she has been able to help so many people learn to make healthier choices for themselves. Through her work, she has connected with so many incredible people in the industry whether other authors, influencers, or brands. Plus, she is affectionately known as "Techie Spice" because of her ability to wrap her head around technology. Every day she gets up with a renewed sense of energy and ready to make a difference. You can read all of Lisa's content here. In her spare time, Lisa loves to try new recipes, make delicious and nourishing meals, and she is an avid reader. For more information about Lisa, check out her profile on here.